| 効果 | 減少 |
| 試験方法 | コホート法 |
| 試験期間 | 2-4 週間 |
| 被験者数 | 90 |
| 性別 | 男女 |
| 年齢 | 65+ |
In an unblinded study, the efficacy of a 1.33% betaine mouthwash was tested and found to improve symptoms of dry mouth induced by pharmaceuticals over the course of four weeks; the benefits were not additive with an intraoral device (mouthguard) despite the two being comparable in efficacy.
No placebo control, symptoms relative to baseline and 63% of persons reported benefit from treatment (7 ratings of beneficial, 12 of minor benefit, none of major benefit, 10 reporting no change, 1 worsening).
Safety And Effectiveness Of Topical Dry Mouth Products Containing Olive Oil, Betaine, And Xylitol In Reducing Xerostomia For Polypharmacy-induced Dry Mouth
| 効果 | 減少 |
| 試験方法 | コホート法 |
| 試験期間 | 1-7 Days |
| 被験者数 | 40 |
| 性別 | 男女 |
| 年齢 | 65+ |
A pilot study tested a 1.33% betaine solution (albeit with olive oil and xylitol possibly also being bioactive) has noted benefits to dry mouth symptoms relative to unblinded control.
Betaine-containing Toothpaste Relieves Subjective Symptoms Of Dry Mouth
| 効果 | 減少 |
| 試験方法 | コホート法 |
| 試験期間 | 1-2 週間 |
| 被験者数 | 13 |
| 性別 | 女性 |
| 年齢 | 65+ |
Twice daily brushing of a toothpaste containing 4% betaine by weight in persons with dry mouth symptoms appears to be able to reduce said symptoms as assessed by self-reported, with no apparent changes in the visual appearance of the mucosa or bacterial colonies. Efficacy was greater in those with worse symptoms and lower baseline salivation rates.
Effects Of A Betaine-containing Toothpaste On Subjective Symptoms Of Dry Mouth: A Randomized Clinical Trial
| 効果 | 減少 |
| 試験方法 | 二重盲検法 |
| 試験期間 | 1-6 ヶ月 |
| 被験者数 | 45 |
| 性別 | 男女 |
| 年齢 | 45-64, 65+ |
In subjects either with dry mouth symptoms or healthy controls, a toothpaste containing 4% betaine over the course of six weeks was noted to reduce dry mouth symptoms in persons with dry mouth (beneficially affecting 44% of persons, a level significantly greater than placebo toothpaste) and appeared to have its efficacy reduced in the presence of 1% sodium lauryl sulfate (SLS).