| 効果 | 減少 |
| 試験方法 | 二重盲検法 |
| 試験期間 | 1-6 ヶ月 |
| 被験者数 | 156 |
| 性別 | 男女 |
| 年齢 | 45-64, 65+ |
| 体型 | 肥満, 平均 |
In persons with osteoarthritis given 100mg pycnogenol once daily for 3 months, supplementation was able to more than half (56% reduction) symptoms of osteoarhritis as assessed by the WOMAC rating scale. An improvement in functional scores and reduction in foot edema was also noted (parameter recorded under leg swelling).
Pycnogenol supplementation reduces pain and stiffness and improves physical function in adults with knee osteoarthritis
| 効果 | 減少 |
| 試験方法 | 二重盲検法 |
| 試験期間 | 1-6 ヶ月 |
| 被験者数 | 35 |
| 性別 | 男女 |
| 年齢 | 18-29, 30-44, 45-64 |
| 体型 | 平均 |
In persons with primary grade 1 osteoarthritic symptoms, supplementation of pycnogenol at 50mg thrice daily was noted to, over the course of 90 days, reduce pain and functional impairment associated with osteoarthritis in the range of 35-52% (depending on what was being measured). It took 90 days for this magnitude of benefit to be see, and although all but stiffness benefitted slightly by 60 days there was no effect on day 30.