inositol-fertility

In women with PCOS, supplementation of 2,000mg _myo_-inositol was able to improve oocyte maturation and quality.

6-8 weeks of supplementation with 600mg D-chiro-inositol daily in women with PCOS who also had an average BMI was able to increase ovulation secondary to reducing androgens, and appears to be effective in improving other biomarkers of health such as blood pressure and triglycerides.

2,000mg inositol daily in overweight women with PCOS

A three month pretreatment of inositol supplementation in women with PCOS subject to undergo fertilization therapy noted that inositol at 2,000mg (400mcg folic acid also used as placebo) was more effective than placebo in improving fertilization rates and fertility.

Three months supplementation of inositol at 2g daily in women with PCOS who then subsequently underwent ovarian induction noted that supplementation was associated with improved fertility.

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Supplementation of _myo_-inositol at 4g daily in women with PCOS undergoing ovulation induction for the purpose of intracytoplasmic sperm injections noted that supplementation resulted in improve oocyte maturation and reduced requirements of hormones needed to induce ovulation (rFSH). Pregnancy rates were not affected.

Supplementation of inositol at 2,000mg daily for an average of 35 days was associated with improved fertility and period regulatory over the course of the next six months.

Supplementation of inositol at 4g daily (initially without FSH treatment, but it was introduced in both groups if no pregnancy occurred) was more effective than 1,500mg metformin in improving fertility rates in women with PCOS.

4g of inositol daily for a period of 16 weeks in women with PCOS was ineffective in improving parameters of insulin sensitivity while it was sufficient to improve biomarkers of steroid metabolism and fertility. Weight was decreased in all subjects who were not morbidly obese.