dehydroepiandrosterone-lean-mass

この研究の注釈：

Young male athletes (19-22) were given DHEA at 100mg for 28 days and resulted in increased testosterone and estrogen levels, but did not influence parameters of fat mass or lean mass.

Subjects were soccer players and no mention was made of resistance training.

この研究の注釈：

DHEA supplementation at 50mg did not influence testosterone levels acutely (despite an increase in androstenedione) and 150mg of DHEA was unable to influence testosterone levels over 6 weeks in young healthy men.

No significant differences were seen in placebo versus DHEA at 150mg in regards to strength gain and lean mass accrual.

この研究の注釈：

As an adjunct therapy in stable HIV patients, DHEA was unable to influence bone mineral density and lean mass yet did not show adverse effects in HIV patients and increased well being and quality of life.

この研究の注釈：

100mg of DHEA for 12 weeks in previously weight trained middle aged men was unable to increase lean mass more than placebo, but was not associated with any adverse biochemicular effects.

この研究の注釈：

DHEA, either alone at 50mg daily or in combination with an aromatase inhibitor (atamestane at 100mg) was studied for 36 weeks in otherwise healthy an non-hospitalized older men with low scores on physical strength (frailty).

Testosterone increased in all groups, with the DHEA+AI group increasing more than double that of DHEA or AI alone (8.5, 3.5, 4.9nmol/L respectively), DHEA+AI had about 1.3rd the increase in estrogen seen in DHEA, while AI saw a decrease relative to placebo. IGF-1 increased in all groups, but only significantly in the combination. The combination seemed to improve body composition, but was statistically insignificant.

Cognitive decline was measured via MMSE but showed no influence with DHEA, and the changes in IGF binding proteins were too variable to be significant (although an interaction seemed to be present)

この研究の注釈：

1 year of 50mg daily DHEA in older men and women aged 60-80, and had no influence on body composition nor strength in free-living persons not subject to an exercise protocol.

この研究の注釈：

DHEA at 50mg daily in menopausal women does not influence muscle mass, libido, sleep quality or well being despite increasing circulating androgen status. Estrone and SHBG were unaffected alongside cortisol. Functional tests failed to show a protective effect of either DHEA or estrogen replacement therapy (active control) and power output (knee flexion) was unaffected. Cholesterol decreased 8%.

この研究の注釈：

50mg of DHEA take daily for 1 year in otherwise healthy but aged individuals of both genders was able to reduce fasting triglycerides and HDL-C, but was unable to influence other measured parameters and body composition.