Effects Of Dehydroepiandrosterone And Atamestane Supplementation On Frailty In Elderly Men
| 効果 | なし |
| 試験方法 | 二重盲検法 |
| 試験期間 | 6+ ヶ月 |
| 被験者数 | 83 |
| 性別 | 男性 |
| 年齢 | 65+ |
| 体型 | 肥満 |
この研究の注釈：
DHEA, either alone at 50mg daily or in combination with an aromatase inhibitor (atamestane at 100mg) was studied for 36 weeks in otherwise healthy an non-hospitalized older men with low scores on physical strength (frailty).
DHEA, either alone at 50mg daily or in combination with an aromatase inhibitor (atamestane at 100mg) was studied for 36 weeks in otherwise healthy an non-hospitalized older men with low scores on physical strength (frailty).
Testosterone increased in all groups, with the DHEA+AI group increasing more than double that of DHEA or AI alone (8.5, 3.5, 4.9nmol/L respectively), DHEA+AI had about 1.3rd the increase in estrogen seen in DHEA, while AI saw a decrease relative to placebo. IGF-1 increased in all groups, but only significantly in the combination. The combination seemed to improve body composition, but was statistically insignificant.
Cognitive decline was measured via MMSE but showed no influence with DHEA, and the changes in IGF binding proteins were too variable to be significant (although an interaction seemed to be present)