dehydroepiandrosterone-fat-mass

この研究の注釈：

Young male athletes (19-22) were given DHEA at 100mg for 28 days and resulted in increased testosterone and estrogen levels, but did not influence parameters of fat mass or lean mass.

Subjects were soccer players and no mention was made of resistance training.

この研究の注釈：

DHEA supplementation at 50mg did not influence testosterone levels acutely (despite an increase in androstenedione) and 150mg of DHEA was unable to influence testosterone levels over 6 weeks in young healthy men.

No significant differences were seen in placebo versus DHEA at 150mg in regards to strength gain and lean mass accrual.

この研究の注釈：

50mg of DHEA over 12 weeks in healthy postmenopausal women with an average age of 64.6yrs and who were sedentary at the start of the study.

With the introduction of exercise, beneficial changes in body composition were due to exercise and there was no difference in the DHEA group relative to placebo.

A reduction in small dense LDL particles (oxidized LDL usually) was noted.

研究の資金源に関する問題点：

NIH grant, likely a nonissue

この研究の注釈：

50mg of DHEA given for 3 months in a double blind manner to aged men with low circulating DHEA levels but otherwise healthy status was unable to significantly influence any study parameter despite increasing circulating DHEA levels. The only effect that was notable was an increasing trend to increase LDL and Triglycerides, which did not reach statistical significance.

この研究の注釈：

DHEA, either alone at 50mg daily or in combination with an aromatase inhibitor (atamestane at 100mg) was studied for 36 weeks in otherwise healthy an non-hospitalized older men with low scores on physical strength (frailty).

Testosterone increased in all groups, with the DHEA+AI group increasing more than double that of DHEA or AI alone (8.5, 3.5, 4.9nmol/L respectively), DHEA+AI had about 1.3rd the increase in estrogen seen in DHEA, while AI saw a decrease relative to placebo. IGF-1 increased in all groups, but only significantly in the combination. The combination seemed to improve body composition, but was statistically insignificant.

Cognitive decline was measured via MMSE but showed no influence with DHEA, and the changes in IGF binding proteins were too variable to be significant (although an interaction seemed to be present)

この研究の注釈：

1 year of 50mg daily DHEA in older men and women aged 60-80, and had no influence on body composition nor strength in free-living persons not subject to an exercise protocol.

この研究の注釈：

50mg of DHEA take daily for 1 year in otherwise healthy but aged individuals of both genders was able to reduce fasting triglycerides and HDL-C, but was unable to influence other measured parameters and body composition.

この研究の注釈：

DHEA at 50mg for 4 months was unable to influence serum testosterone levels in men, while it increased testosterone levels only in women with low circulating androgens. SHBG dropped in men and women, and DHEA-S in serum increased in both groups.

No effects on carbohydate metabolism or insulin sensitivity were seen. Fat mass decreased, no effects on well being and quality of life were seen.

Patients were hypoadrenics.