dehydroepiandrosterone-estrogen

この研究の注釈：

Young male athletes (19-22) were given DHEA at 100mg for 28 days and resulted in increased testosterone and estrogen levels, but did not influence parameters of fat mass or lean mass.

Subjects were soccer players and no mention was made of resistance training.

この研究の注釈：

DHEA supplementation at 50mg did not influence testosterone levels acutely (despite an increase in androstenedione) and 150mg of DHEA was unable to influence testosterone levels over 6 weeks in young healthy men.

No significant differences were seen in placebo versus DHEA at 150mg in regards to strength gain and lean mass accrual.

この研究の注釈：

27 older frail women given DHEA over 6 months improved at cognitive parameters such as verbal fluency while the control group deteriorated.

この研究の注釈：

25mg of DHEA over 12 months was able to increase all steroid hormones in the serum, including the neurosteroids allopregnanolone and beta-endorphin. SHBG also decreased alongside cortisol, and overall menopausal symptoms in these women was decreased.

この研究の注釈：

50mg of DHEA given daily for 6 months to older frail women*was unable to significantly affect bone mineral density over 6 months yet increased serum steroid status (testosterone, estrogen, DHEA) and increased lower body strength and functionality when DHEA was used in conjunction with non-strenuous exercises.

この研究の注釈：

Circulating steroids increased after low dose (25mg) DHEA administration for up to a year, yet after 3 months of supplementation cortisol appeared to decline and the adrenal glands released less cortiol in response to ACTH hormone stimulation; suggesting a modification of the stress response. 17-hydroxyprogresterone only increased during months 6-12, not month 3.

Subjects were otherwise healthy menopausal women aged 50-65/

この研究の注釈：

50mg of DHEA over 12 weeks in healthy postmenopausal women with an average age of 64.6yrs and who were sedentary at the start of the study.

With the introduction of exercise, beneficial changes in body composition were due to exercise and there was no difference in the DHEA group relative to placebo.

A reduction in small dense LDL particles (oxidized LDL usually) was noted.

研究の資金源に関する問題点：

NIH grant, likely a nonissue

この研究の注釈：

50mg of DHEA over 6 months in menopausal women showed that testosterone and estrogen increased, while SHBG decreased only in overweight women significantly. Plasma levels of neurosteroids (beta-endorphin and allopregnanolone) increased while cortisol and gonadotropins decreased.

SHBG decreased only in the subset of postmenopausal women who were older and overweight.

この研究の注釈：

50mg of DHEA given for 3 months in a double blind manner to aged men with low circulating DHEA levels but otherwise healthy status was unable to significantly influence any study parameter despite increasing circulating DHEA levels. The only effect that was notable was an increasing trend to increase LDL and Triglycerides, which did not reach statistical significance.

この研究の注釈：

DHEA, either alone at 50mg daily or in combination with an aromatase inhibitor (atamestane at 100mg) was studied for 36 weeks in otherwise healthy an non-hospitalized older men with low scores on physical strength (frailty).

Testosterone increased in all groups, with the DHEA+AI group increasing more than double that of DHEA or AI alone (8.5, 3.5, 4.9nmol/L respectively), DHEA+AI had about 1.3rd the increase in estrogen seen in DHEA, while AI saw a decrease relative to placebo. IGF-1 increased in all groups, but only significantly in the combination. The combination seemed to improve body composition, but was statistically insignificant.

Cognitive decline was measured via MMSE but showed no influence with DHEA, and the changes in IGF binding proteins were too variable to be significant (although an interaction seemed to be present)

この研究の注釈：

In elderly men given DHEA at 90mg daily, there was no significant effect over 6 months in regards to bone mineral density nor bone turnover rates.

この研究の注釈：

DHEA at 50mg daily in menopausal women does not influence muscle mass, libido, sleep quality or well being despite increasing circulating androgen status. Estrone and SHBG were unaffected alongside cortisol. Functional tests failed to show a protective effect of either DHEA or estrogen replacement therapy (active control) and power output (knee flexion) was unaffected. Cholesterol decreased 8%.

この研究の注釈：

*Confounded with low dose [Vitamin D] and high-dose calcium [Calcium], although placebo group took those supplements as well and thus it is unlikely to influence final results*

Over 2 years of supplementation at 50mg daily in older individuals, testosterone estrogen and IGF-1 increase in groups consuming DHEA.

Bone mineral density increased in women, but not men.

この研究の注釈：

2 months of DHEA supplements, 50mg at bedtime, was able to increase circulating levels of Platelet cyclic guanosine-monophosphate, a biomarker for Nitric Oxide.

It increased testosterone and estrogen, as well as plasminogen activating factor-1. Interestingly, DHEA also lowered LDL. Other biomarkers measured were not significantly affected.