| 効果 | 増加 |
| 試験方法 | 二重盲検法 |
| 試験期間 | 不明 |
| 被験者数 | 225 |
| 性別 | 不明 |
50mg of DHEA for a year had a small but significant increase in bone mineral density in women but had no effect in men.
Dehydroepiandrosterone (DHEA) Effects On HIV Replication And Host Immunity: A Randomized Placebo-controlled Study
| 効果 | なし |
| 試験方法 | 二重盲検法 |
| 試験期間 | 不明 |
| 被験者数 | 40 |
| 性別 | 不明 |
As an adjunct therapy in stable HIV patients, DHEA was unable to influence bone mineral density and lean mass yet did not show adverse effects in HIV patients and increased well being and quality of life.
Dehydroepiandrosterone Combined With Exercise Improves Muscle Strength And Physical Function In Frail Older Women
| 効果 | なし |
| 試験方法 | 二重盲検法 |
| 試験期間 | 1-6 ヶ月 |
| 被験者数 | 99 |
| 性別 | 女性 |
| 年齢 | 65+ |
| 体型 | 肥満 |
50mg of DHEA given daily for 6 months to older frail women*was unable to significantly affect bone mineral density over 6 months yet increased serum steroid status (testosterone, estrogen, DHEA) and increased lower body strength and functionality when DHEA was used in conjunction with non-strenuous exercises.
Effects Of Dehydroepiandrosterone And Atamestane Supplementation On Frailty In Elderly Men
| 効果 | なし |
| 試験方法 | 二重盲検法 |
| 試験期間 | 6+ ヶ月 |
| 被験者数 | 83 |
| 性別 | 男性 |
| 年齢 | 65+ |
| 体型 | 肥満 |
DHEA, either alone at 50mg daily or in combination with an aromatase inhibitor (atamestane at 100mg) was studied for 36 weeks in otherwise healthy an non-hospitalized older men with low scores on physical strength (frailty).
Testosterone increased in all groups, with the DHEA+AI group increasing more than double that of DHEA or AI alone (8.5, 3.5, 4.9nmol/L respectively), DHEA+AI had about 1.3rd the increase in estrogen seen in DHEA, while AI saw a decrease relative to placebo. IGF-1 increased in all groups, but only significantly in the combination. The combination seemed to improve body composition, but was statistically insignificant.
Cognitive decline was measured via MMSE but showed no influence with DHEA, and the changes in IGF binding proteins were too variable to be significant (although an interaction seemed to be present)
Dehydroepiandrosterone Supplementation And Bone Turnover In Middle-aged To Elderly Men
| 効果 | なし |
| 試験方法 | 二重盲検法 |
| 試験期間 | 不明 |
| 被験者数 | 43 |
| 性別 | 不明 |
In elderly men given DHEA at 90mg daily, there was no significant effect over 6 months in regards to bone mineral density nor bone turnover rates.
Dehydroepiandrosterone Replacement Therapy In Older Adults: 1- And 2-y Effects On Bone
| 効果 | なし |
| 試験方法 | 二重盲検法 |
| 試験期間 | 6+ ヶ月 |
| 被験者数 | 113 |
| 性別 | 男女 |
| 年齢 | 65+ |
| 体型 | 肥満 |
*Confounded with low dose [Vitamin D] and high-dose calcium [Calcium], although placebo group took those supplements as well and thus it is unlikely to influence final results*
Over 2 years of supplementation at 50mg daily in older individuals, testosterone estrogen and IGF-1 increase in groups consuming DHEA.
Bone mineral density increased in women, but not men.
Dehydroepiandrosterone Replacement Therapy In Older Adults: 1- And 2-y Effects On Bone
| 効果 | 増加 |
| 試験方法 | 二重盲検法 |
| 試験期間 | 6+ ヶ月 |
| 被験者数 | 113 |
| 性別 | 男女 |
| 年齢 | 65+ |
| 体型 | 肥満 |
*Confounded with low dose [Vitamin D] and high-dose calcium [Calcium], although placebo group took those supplements as well and thus it is unlikely to influence final results*
Over 2 years of supplementation at 50mg daily in older individuals, testosterone estrogen and IGF-1 increase in groups consuming DHEA.
Bone mineral density increased in women, but not men.