d-serine-symptoms-of-schizophrenia

D-Serine at doses between 30-120mg/kg was dose-dependently effective in reducing all symptoms of schizophrenia, with 30mg/kg being ineffective on some (but not all) parameters. Improvements in symptoms appeared to correlate with blood D-serine concentrations

In 60 persons with schizophrenia given 2,000mg D-serine daily for 6 weeks, D-serine supplementation failed to outperform placebo on all measured parameters while the reference drug (sarcosine) was effective at the same dose.

Supplementation of 30mg/kg D-serine to schizophrenic patients for 6 weeks was able to reduce all symptoms of schizophrenia, and serum concentrations of D-serine were able to predict the improvements seen in rating scales.

30mg/kg of D-serine daily in addition to antipsychotic therapy (risperidone or olanzapine) was able to improve negative, positive, depressive, and cognitive scores over 6 weeks with the improvement on symptoms being 4.3-20.6% (95% CI of SAS rating scale), 19.8-57.7% (95% CI of AIMS), and 14 patients on D-serine noted over a 20% improvement on negative and positive symptoms while only 2 subjects on placebo did.

6 weeks supplementation of 2,000mg D-serine (compared to both placebo and an equal dose of sarcosine) has failed to outperform placebo when both were added to risperidone therapy.

スポンサーリンク

In 195 persons with schizophrenia already on antipsychotic treatment, the addition of 2,000mg D-serine daily for 16 weeks failed to outperform placebo at controlling positive and negative symptoms of schizophrenia and failed to significantly affect cognition.