d-serine-cognition

Supplementation of 30mg/kg D-serine to schizophrenic patients for 6 weeks was able to reduce all symptoms of schizophrenia, and serum concentrations of D-serine were able to predict the improvements seen in rating scales.

30mg/kg of D-serine daily in addition to antipsychotic therapy (risperidone or olanzapine) was able to improve negative, positive, depressive, and cognitive scores over 6 weeks with the improvement on symptoms being 4.3-20.6% (95% CI of SAS rating scale), 19.8-57.7% (95% CI of AIMS), and 14 patients on D-serine noted over a 20% improvement on negative and positive symptoms while only 2 subjects on placebo did.

In 195 persons with schizophrenia already on antipsychotic treatment, the addition of 2,000mg D-serine daily for 16 weeks failed to outperform placebo at controlling positive and negative symptoms of schizophrenia and failed to significantly affect cognition.