creatine-treatment-of-amyotrophic-lateral-sclerosis-als

この研究の注釈：

According to a meta-analysis, 5-10 g/day in persons with Amyotrophic Lateral Sclerosis (ALS) has failed to alter the degenerative nature of the disease and to exert significant protective effects relative to placebo or control.

この研究の注釈：

In patients with probable/definite Amyotrophic Lateral Sclerosis (ALS), creatine monohydrate enhanced Maximal Voluntary Isometric Contraction (MVIC) significantly at the elbow (53% of subjects) and knee (70% of subjects) after the 1-week loading phase (20 g/day). However, over the 6-month maintenance phase (3 g/day), the rates of decline for both the upper and lower limbs were not statistically different from the rates of decline before treatment, suggesting no longer-term effect.

The study saw many dropouts due to initial diarrhea from the loading phase, but no abnormalities were detected in the kidney or the liver.

この研究の注釈：

20g of creatine taken for a five day loading period followed by 5g of creatine monohydrate for the remainder of the six month trial failed to attenuate the rate of musclular power loss seen with ALS any more than placebo, although treatment was well tolerated.

この研究の注釈：

10 g/day (5 g twice a day) for 16 months, as an adjuvant to riluzole, attenuated the loss rate of muscle strength but not of lung function. Survival was not affected to a significant extent. The treatment was well tolerated.

この研究の注釈：

5 g/day for 9 months (following 10 g/day for five days) failed to benefit well-being, functional capacity, lung function, or muscular capacity as assessed by Maximal Voluntary Isometric Contraction (MVIC). The treatment proved safe, however, and the risk of death was nonsignificantly reduced.

この研究の注釈：

In patients with Amyotrophic Lateral Sclerosis (ALS), 5 g/day failed to benefit lung function (FEV, maximal capacity, forced vital capacity, etc.). Patients dropped out from the study when they had to go on mechanical ventilation, were unable to make their visits to the clinic due to severe motor deterioration, or died. Out of 14 patients, 9 lasted for 6 months, and only 1 for 9 months.