creatine-total-cholesterol

No affect of creatine supplementation on blood lipoprotein or cholesterol parameters, although aerboic exercise reduced them.

In athletes who reported (retrospectively) creatine usage for up to four years, there was no significant adverse effect on healthy markers, although a nonsignificant trend to increase testosterone and decrease LDH (lactate dehydrogenase, a liver enzyme) was noted.

In subjects with cholesterol exceeding 200 mg/dL, creatine supplementation (20 g/day for 5 days followed by 5 g/day for 56 days) reduced triglycerides by 23%, total cholesterol by 5-6%, and vLDL by 22%, without much effect on LDL or HDL. Urea increased mildly (17%) in women only.

50 mg/kg/day (approximately 3.5 g, alongside 30 g of sucrose) for 6 weeks increased the circulating triglycerides and body fat percentage (+0.17%) of martial artists, but not their fat mass. Lactate and liver enzymes were lower, relative to placebo, but not to a significant extent.