creatine-subjective-well-being

この研究の注釈：

Supplementation of 20g creatine for five days followed by 5g a day for the remainder of the 12 week trial in women with osteoarthritis noted that supplementation was able to significantly reduce knee stiffness (52%), pain (45%), and physical function (41%) relative to baseline, all values being significantly more than placebo.

この研究の注釈：

In otherwise healthy men subject to sleep deprivation after 7 days of creatine loading, supplementation failed to have any effect when measured at 12-24 hours yet was able to improve executive functioning at 36 hours. Mood, cortisol, and memory were all still unaffected relative to placebo.

この研究の注釈：

When lesser intensity chemotherapies were controlled for, creatine supplementation improved Phase Angle measurements (an indicator of Body Cell Mass and vitality). Statistically insignificant results when chemotherapy intensity was not controlled for.

Loading phase of 20g daily (four doses) for 5 days, reduced to 5g daily (two doses) for the remainder of the trial.

No effects on quality of life and subjective well-being of colorectal cancer patients. No beneficial effects noted on muscle function or mass in this population either.

この研究の注釈：

Patients with Congestive Heart Failure (CHF) had increases in body weight and strength when using creatine monohydrate at 20g daily (no loading or maintenance, but a continual dosage for 6 weeks) but no improvement in cardiovascular exercise capacity.

この研究の注釈：

A week of creatine loading prior to sleep deprivation appears to not influence cortisol or serum catecholamines, but was associated with less reports of fatigue and more vigor relative to placebo. Despite the improved mood state, cognition during the 24 hours of testing was not significantly altered

この研究の注釈：

In youth (8-18) given supplemental creatine at 12g for a week and then 6g daily for 11 weeks, creatine caused a time-dependent increase in muscle force production and improved well being, but it did not improve chest or lung function (main outcome measures of cystic fibrosis).

この研究の注釈：

In children with mitochondrial encephalomyopathy (n=4), an unblinded series of controlled case studies found that 100-200 mg/kg/day for at least 3 months improved both physical endurance (30-57% in three patients) and power output (8-17%) relative to baseline. An increase in daily function and quality of life was also reported. These benefits declined to baseline values when creatine supplementation was stopped.

The myopathies in this study were MELAS (n=1), KSS (n=2), and NARP (n=1).

この研究の注釈：

Supplementation of persons with creatine at 22g daily for a five day loading phase (with 20g lactose) and then a maintenance phase of 3.76g creatine (5g lactose) daily for a period of seven weeks failed to increase any parameter of physical performance or muscular strength relative to placebo, despite a weight gain seen with supplementation.

この研究の注釈：

2 year trial of creatine monohydrate supplementation on Parkinson’s Disease.

Improvements in mood noted, but no improvements on parameters of Parkinson’s disease (as measured by the Unified Parkinson’s Disease Rating Scale)

この研究の注釈：

In persons with COPD given supplementation of either placebo (glucose) or creatine (5.7g) with glucose (35.7g) thrice daily to match placebo over two weeks, then with 5.7g once daily for 11 weeks, supplementation was associated with improvements in muscular strength and well being as well as an increase in weight that was not fat mass; cardiovascular exercise performance, however, was unaffected.

この研究の注釈：

5 g/day for 9 months (following 10 g/day for five days) failed to benefit well-being, functional capacity, lung function, or muscular capacity as assessed by Maximal Voluntary Isometric Contraction (MVIC). The treatment proved safe, however, and the risk of death was nonsignificantly reduced.