creatine-kidney-function

No effect in post-menopausal women.

Type II diabetic patients

Typical loading protocol (20g for 5 days, 5g for 30 days)

Hepatic (liver) markers also normal, uric acid tended to decrease as well as serum glucose levels.

10g a day dosage, given to sedentary males at the onset of an exercise regimen for 12 weeks. No renal disturbances noted.

No adverse blood parameters were noted, and indirect evidence for lack of kidney complications was given.

Primary investigation was into whether creatine could reduce homocysteine levels at 2g/day in hemodialysis patients already taking B6, Folate, and B12. This investigation proved to be non-significant (no decreases were seen)

Effects noted in both men and women, but men more responsive. At least in those given a new workout regimen, there was no significant difference in the gains in power and strength over 6 weeks when working out twice a week relative to thrice a week.

Uric acid and blood glucose tended to decrease, while liver and kidney function showed no adverse signs.

20g of creatine taken for a five day loading period followed by 5g of creatine monohydrate for the remainder of the six month trial failed to attenuate the rate of musclular power loss seen with ALS any more than placebo, although treatment was well tolerated.

10 g/day (5 g twice a day) for 16 months, as an adjuvant to riluzole, attenuated the loss rate of muscle strength but not of lung function. Survival was not affected to a significant extent. The treatment was well tolerated.

300 mg/kg/day for 7 days increased body mass (0.75 kg) and power output during sprints in the heat, but did not appear to influence heat tolerance or any parameter of cardiovascular health. A greater (relative to placebo) exercise-induced increase in aldosterone was also noted.

Over an average 310 days, individuals aged 57±11.1 years received either creatine (10 g/day) or a placebo. In the creatine group, nausea was lower by 1%, gastrointestinal discomfort higher by 1%, and diarrhea higher by 10% (all non-significant numbers). No changes were noted in long-term urea or microalbuminuria measures.