Creatine Monohydrate Enhances Strength And Body Composition In Duchenne Muscular Dystrophy
効果 | なし |
試験方法 | 二重盲検法 |
試験期間 | 1-6 ヶ月 |
被験者数 | 30 |
性別 | 男性 |
年齢 | 7-12 |
体型 | 肥満, 肥満 |
In thirty children given creatine supplementation at around 2-5g daily (half of which were on corticosteroids) for four months of time, supplementation of creatine was associated with an increase in strength of the dominant hand (but not the other) and an almost significant reduction in whole body strength seen in placebo was prevented with creatine.
There were no improvements on activities of daily living or lung function, and there was no influence on DNA damage as assessed by the 8-OH-2-dG/creatinine ratio (but creatinine was also unaffected).
Creatine Supplementation And Health Variables: A Retrospective Study
効果 | 増加 |
試験方法 | コントロールなし/観察研究 |
試験期間 | 不明 |
被験者数 | 26 |
性別 | 男女 |
年齢 | 18-29 |
体型 | トレーニング中, 平均 |
In athletes who reported (retrospectively) creatine usage for up to four years, there was no significant adverse effect on healthy markers, although a nonsignificant trend to increase testosterone and decrease LDH (lactate dehydrogenase, a liver enzyme) was noted.
Effects Of Creatine Supplementation On Oxidative Stress And Inflammatory Markers After Repeated-sprint Exercise In Humans
効果 | 増加 |
試験方法 | 二重盲検法 |
試験期間 | 1-7 Days |
被験者数 | 25 |
性別 | 男性 |
年齢 | 13-17, 18-29 |
体型 | トレーニング中, 平均 |
In youth, 300 mg/kg/day for 1 week was able to improve performance on a repeated sprint test (35-m sprints, repeated six times with 10-s rests) relative to placebo, but this was not associated with any change in fatigue (assessed via fatigue index) or in biomarkers of oxidative stress, although inflammation was attenuated.
There were unclear effects on muscle damage, since creatine kinase increased while LDH (lactate dehydrogenase, a liver enzyme) decreased.
A Clinical Trial Of Creatine In ALS
効果 | なし |
試験方法 | 二重盲検法 |
試験期間 | 1-6 ヶ月 |
被験者数 | 85 |
性別 | 男女 |
年齢 | 45-64, 65+ |
体型 | 平均 |
20g of creatine taken for a five day loading period followed by 5g of creatine monohydrate for the remainder of the six month trial failed to attenuate the rate of musclular power loss seen with ALS any more than placebo, although treatment was well tolerated.
Effects Of Creatine Supplementation On The Performance And Body Composition Of Competitive Swimmers
効果 | 増加 |
試験方法 | 二重盲検法 |
試験期間 | 1-2 週間 |
被験者数 | 18 |
性別 | 不明 |
年齢 | 18-29 |
体型 | トレーニング中, 平均 |
Supplementation of a loading phase of creatine (20g in four divided doses of 5g for eight days) in elite swimmers failed to improve performance in a 100m sprint despite increasing body weight and water weight (no influence on muscle mass or fat mass)
The Effect Of Creatine Supplementation On Muscle Fatigue And Physiological Indices Following Intermittent Swimming Bouts
効果 | なし |
試験方法 | 二重盲検法 |
試験期間 | 1-7 Days |
被験者数 | 16 |
性別 | 男性 |
年齢 | 13-17, 18-29 |
体型 | トレーニング中, 平均 |
5 g taken four times a day (20 g/day) for 6 days was able to improve intermittent sprint performance (a 50-m sprint conducted six times with a 2-minute break in between). The decrease in speed on the third sprint was reduced from 5% to 2%, but was nonsignifiant after the sixth sprint. Biochemical parameters (heart rate, lactate, creatinine) were unaltered.
Creatine Monohydrate Supplementation Does Not Increase Muscle Strength, Lean Body Mass, Or Muscle Phosphocreatine In Patients With Myotonic Dystrophy Type 1
効果 | 増加 |
試験方法 | 二重盲検法 |
試験期間 | 1-6 ヶ月 |
被験者数 | 34 |
性別 | 男女 |
年齢 | 45-64, 65+ |
体型 | 平均 |
5 g/day for 4 months in individuals with myotonic dystrophy type I (DM1) failed to improve muscular strength (handgrip) or lung function (FEV1) relative to placebo, nor was there any influence on functional tests or biochemical parameters.
Effects Of Long-term Creatine Supplementation On Liver And Kidney Functions In American College Football Players
効果 | なし |
試験方法 | コントロールなし/観察研究 |
試験期間 | 不明 |
被験者数 | 23 |
性別 | 男性 |
年齢 | 18-29 |
This retrospective study failed to find a link between creatine supplementation and any biomarker of health, suggesting no ill effects.
Creatine Has No Beneficial Effect On Skeletal Muscle Energy Metabolism In Patients With Single Mitochondrial DNA Deletions: A Placebo-controlled, Double-blind 31P-MRS Crossover Study
効果 | なし |
試験方法 | 二重盲検法 |
試験期間 | 2-4 週間 |
被験者数 | 15 |
性別 | 男女 |
年齢 | 30-44, 45-64 |
In subjects with mitochondrial disorders associated with single gene deletions that affect the muscles around the eyes (CPEO or KSS), 150 mg/kg/day for 6 weeks failed to improve well-being, power output (handgrip strength test), or any other parameter of exercise, relative to placebo.
High-performance Capillary Electrophoresis-pure Creatine Monohydrate Reduces Blood Lipids In Men And Women
効果 | なし |
試験方法 | 二重盲検法 |
試験期間 | 1-6 ヶ月 |
被験者数 | 34 |
性別 | 男女 |
年齢 | 30-44, 45-64 |
体型 | 肥満 |
In subjects with cholesterol exceeding 200 mg/dL, creatine supplementation (20 g/day for 5 days followed by 5 g/day for 56 days) reduced triglycerides by 23%, total cholesterol by 5-6%, and vLDL by 22%, without much effect on LDL or HDL. Urea increased mildly (17%) in women only.
Physiological Responses To Short-term Exercise In The Heat After Creatine Loading
効果 | 増加 |
試験方法 | 二重盲検法 |
試験期間 | 1-7 Days |
被験者数 | 20 |
性別 | 男性 |
年齢 | 18-29 |
体型 | 平均 |
300 mg/kg/day for 7 days increased body mass (0.75 kg) and power output during sprints in the heat, but did not appear to influence heat tolerance or any parameter of cardiovascular health. A greater (relative to placebo) exercise-induced increase in aldosterone was also noted.
Effects Of Creatine Supplementation In Taekwondo Practitioners
効果 | なし |
試験方法 | 二重盲検法 |
試験期間 | 1-6 ヶ月 |
被験者数 | 10 |
性別 | 男性 |
年齢 | 18-29 |
体型 | トレーニング中, 平均 |
50 mg/kg/day (approximately 3.5 g, alongside 30 g of sucrose) for 6 weeks increased the circulating triglycerides and body fat percentage (+0.17%) of martial artists, but not their fat mass. Lactate and liver enzymes were lower, relative to placebo, but not to a significant extent.