creatine-blood-glucose

A loading phase of creatine followed by maintenance for 11 weeks in otherwise healthy sedentary males appears to reduce glucose following an oral glucose tolerance test (11-22%) with efficacy at 4 weeks and no further efficacy at 12 weeks; there was no significant influence on insulin sensitivity (assessed via HOMA) nor serum insulin.

In subjects with cholesterol exceeding 200 mg/dL, creatine supplementation (20 g/day for 5 days followed by 5 g/day for 56 days) reduced triglycerides by 23%, total cholesterol by 5-6%, and vLDL by 22%, without much effect on LDL or HDL. Urea increased mildly (17%) in women only.

50 mg/kg/day (approximately 3.5 g, alongside 30 g of sucrose) for 6 weeks increased the circulating triglycerides and body fat percentage (+0.17%) of martial artists, but not their fat mass. Lactate and liver enzymes were lower, relative to placebo, but not to a significant extent.

5 g/day given to vegetarians for 42 days was associated with a nonsignificant elevation of blood glucose levels (both fasting and postprandial) and no alteration in insulin levels (both fasting and postprandial).