conjugated-linoleic-acid-liver-enzymes

この研究の注釈：

In healthy and overweight (BMI 25-35) Japanese volunteers, 3.4 and 6.8g CLA (50/50 isomer blend) was paired against safflower oil for 12 weeks found no significant adverse effects for the persons who were healthy at baseline, and some slight abnormalities with liver enzymes (ALT and AST) at the higher dose of CLA (6.8g) at the end of the 12 weeks in person with less healthy baseline statistics.

Doses of 3.4g daily deemed safe.

この研究の注釈：

In healthy and overweight (BMI 25-35) Japanese volunteers, 3.4 and 6.8g CLA (50/50 isomer blend) was paired against safflower oil for 12 weeks found no significant adverse effects for the persons who were healthy at baseline, and some slight abnormalities with liver enzymes (ALT and AST) at the higher dose of CLA (6.8g) at the end of the 12 weeks in person with less healthy baseline statistics.

Doses of 3.4g daily deemed safe.

この研究の注釈：

6g of CLA daily for 6 months in obese humans did not significantly reduce fat mass relative to placebo.

AST levels were significantly lower with CLA than placebo (sunflower oil), triglycerides increased at 52 weeks to 150.5mg/dL from 118.2mg/dL (control)

この研究の注釈：

In healthy overweight humans, CLA taken at 3.4g for 2 years was able to reduce fat mass and did not influence lean mass.

Aspartate Amino transferase (liver enzyme) increased, but alanine amino transferase did not. Glucose was unchanged, body fat mass was reduced by 1.7+/-2.8kg over 2 years with no effects in the first year; bone mineral density and lean mass were unaffected.

この研究の注釈：

2.2g of CLA daily for 3 weeks (1g of both main isomers) in healthy Japanese adults was able to increase TGs to about 112% of baseline levels, without significantly influencing lipoprotein metabolism or liver enzymes.

この研究の注釈：

No effects on AST or ALT noted after 3.5g CLA of either mixed isomers, or either the c9t11 or t10c12 isomers in isolation. One group also took 200mg vitamin E and another group 12.5mg Rofecoxib, over 6 weeks in otherwise healthy persons.

この研究の注釈：

Three groups were done in overweight and unhealthy adults; milk with naturally occurring c9t11 CLA, milk with the same (1.3g/day) content of mixed isomer CLA, and milk with 0.2g CLA (CLA depleted). Each trial period was 8 weeks, with a 4 week washout, and each subject was randomized to each trial period.

No difference was noted in triglycerides or cholesterol levels between treatment periods, nor were liver enzymes altered.

この研究の注釈：

14.6g c9t11 isomer and 4.7g t10c12 isomer (19.3g CLA daily) in healthy subjects daily for 3 weeks showed no clinically relevant changes in liver or kidney function, as assessed by blood parameters; two subjects showed isolated spikes in lactate dehydrogenase.