conjugated-linoleic-acid-insulin-sensitivity

この研究の注釈：

6 months of 3.2g CLA daily was able to reduce body fat by 1+/-2.2kg relative to placebo independent of metabolic rate, physical activity, and diet.

この研究の注釈：

Isolated c9t11 isomer of CLA at 3g daily for 3 months, relative to oleic acid, increased insulin resistance and was highly related to the 50% increase in urinary 8-isoPGF(2)a that was noted.

CLA isomer c9t11, in this study population, was significant associated with an increase in fat mass. Placebo gained 0.53 ± 1.22kg over 3 months, and CLA gained 1.40 ± 1.34kg.

この研究の注釈：

In postmenopausal, diabetic women; CLA at 8g daily for 16 weeks was unable to influence parameters of glucose metabolism (almost reaching significance in decreasing glucose) whereas the control, safflower oil, was able to decrease HbA1c levels.

16 weeks of safflower oil was able to slightly benefit lipid metabolism, and nothing was reported with CLA.

この研究の注釈：

12 weeks of an exercise and diet program paired with placebo or CLA+chromium failed to show any significant differences relative to placebo.

この研究の注釈：

A 6 month trial with 118 subjects taking 3.4g CLA isomers with 50/50 blend of the c9t11 and t10c12 isomers found no influences on insulin sensitivity as assessed by insulin clamp, HOMA, or quantitivative insulin sensitivity calculations.

この研究の注釈：

Butter, at 115g per day, was compared against butter (incorporated into foods). One was enriched with 5.5g CLA (39.4% c9t11, 38.5% t10c12) and the other had insignificant CLA levels, instead having lesser fatty acids and the subjects having to seek out additional fatty acids daily. Dietitian intervention had minimized differences, but some existed between group (CLA group reporting slightly higher caloric and PUFA intake)

Urine 8-iso-PGF2α increased to 183% of the control group after CLA ingestion, an in vivo marker of lipid peroxidation. No other changes were noted.

この研究の注釈：

In reponse to an oral glucose tolerance test, glucose and insulin AUC values were increased by 39% and 20%, respectively, when subjects consumed 4g of CLA daily for 12 weeks. This manifested itself as a lower insulin sensitivity.

この研究の注釈：

In young and otherwise healthy sedentary persons, CLA at 4g daily (35% of both isomers) was able to increase insulin sensitivity in 6 persons, decrease it in 2, and have no overall effect in the last 2. Other 6 subjects had placebo.

この研究の注釈：

In young and otherwise healthy sedentary persons, CLA at 4g daily (35% of both isomers) was able to increase insulin sensitivity in 6 persons, decrease it in 2, and have no overall effect in the last 2. Other 6 subjects had placebo.

この研究の注釈：

Persons aged 35-65 with at least 2 criteria for metabolic syndrome ingested 3g of CLA via 500mL milk, relative to placebo of CLA-free milk, for 12 weeks.

Fat mass only significantly decreased when BMI was controlled for the obese class, and no changes observed in the placebo group.

この研究の注釈：

Glucose was significantly increased by 6.3% and insulin sensitivity (assessed by HOMA) decreased after type II diabetic patients consumed 3g CLA daily for 8 weeks. No effects on CRP or IL-6, and HDL-C increased by 8%.

この研究の注釈：

Relative to safflower oil as a control at 3.5g daily, two experimental groups were used. 3.5g of oil comprising 2.7g of 50/50 CLA isomers, and 3.5g oil comprising 2.7g of jsut the c9t11 isomer. Population was overweight and hyperlipidemic men, and no dietary controls were in place (free-living conditions) over 56 days.

No differences existed in lean mass, fat mass, or weight; nor were any trends noted. A decrease in circulating TNF-a was noted with both CLA treatments, and all other parameters came back statistically insignificant.