colostrum-immunoglobulin-m

Supplementation of colostrum (50g taken in two doses daily; about 3% IgG) in both athletes and sedentary persons for 10 weeks failed to influence both salivary and serum concentrations of IgA, IgM, and IgG; while it appeared that there were less upper respiratory tract symptoms in the latter half of the study with colostrum this did not reach significance.

Supplementation of colostrum at 25g daily (two doses) with a high IgG content (65g/L) for ten days in which the last two days were a glycogen depletion trial followed by an endurance trial (90m at 50% Wmax) failed to alter performance during the glycogen depletion trial (anaerobic), failed to alter immune cell changes during exercise, immunoglobulins in serum, or any measured interleukin or cytokine relative to placebo (skim milk).

In otherwise healthy adult volunteers given 100mL of a colostrum beverage (Bioenervi) for one week where vaccination capsules were also ingested thrice, supplementation appeared to augment the vaccine induced elevations of IgA and IgG, but not IgM, specific to the vaccine despite the total immunoglobulin secreting cells not being altered nor their receptors.