| 効果 | なし |
| 試験方法 | 二重盲検法 |
| 試験期間 | 1-7 日 |
| 被験者数 | 12 |
| 性別 | 男女 |
| 年齢 | 18-29 |
| 体型 | 平均 |
0.18g/kg citrulline supplementation daily for a week (without exercise) failed to significantly influence plasma IGF-1 or insulin and did not affect muscle protein synthesis rates. A 13% decrease in glutamine concentrations in serum was noted.
L-citrulline-malate Influence Over Branched Chain Amino Acid Utilization During Exercise
| 効果 | なし |
| 試験方法 | 二重盲検法 |
| 試験期間 | 24 hours |
| 被験者数 | 17 |
| 性別 | 男性 |
| 年齢 | 18-29 |
| 体型 | トレーニング中, 平均 |
Supplementation of 6g citrulline prior to a prolonged exercise test was associated with an increase in urea (27.1-30.4%) and nitrite (indicative of nitric oxide) and appeared to attenuate the rise in urate. Growth hormone increased 66.8% after exercise
Dose-ranging Effects Of Citrulline Administration On Plasma Amino Acids And Hormonal Patterns In Healthy Subjects: The Citrudose Pharmacokinetic Study
| 効果 | なし |
| 試験方法 | コホート法 |
| 試験期間 | 24 hours |
| 被験者数 | 8 |
| 性別 | 男性 |
| 年齢 | 18-29 |
| 体型 | 平均 |
Graded supplementation of citrulline between 2g and 15g in otherwise healthy adults at rest failed to influence measured hormonal parameters and safety testing failed to find a reduction in blood pressure at rest.
L-citrulline Reduces Time To Exhaustion And Insulin Response To A Graded Exercise Test
| 効果 | 減少 |
| 試験方法 | 二重盲検法 |
| 試験期間 | 24 hours |
| 被験者数 | 17 |
| 性別 | 男女 |
| 年齢 | 18-29, 30-44 |
| 体型 | 肥満, 平均 |
In an incline walking test until failure in otherwise healthy persons, 3 or 9g citrulline (acutely or over 24 hours, respectively) appeared to actually reduce time to exhaustion (0.8%, a clinically irrelevant degree) and suppressed the exercise-induced increase in insulin. Other biomarkers tested were unaltered, although heart rate trended to decrease with 3g citrulline