citrulline-fatigue

Supplementation with 8g citrulline (as malate, with 10g sugar that was also used in placebo condition) during a weight lifting protocol (perform as many reps as possible until fatigue for multiple sets) noted that citrulline was able to delay fatigue and promote more reps performed per set for all sets except the first two and reduced post-workout muscle soreness.

In men complaining of fatigue and given citrulline at 6g daily for 22 days, there was an increase in creatine phosphate resynthesis rates and reduced reports of fatigue. A large increase in aerobic ATP production was noted on day 3 (34%), but since it was attenuated back to baseline at day 15 the results were not statistically significant.

In an incline walking test until failure in otherwise healthy persons, 3 or 9g citrulline (acutely or over 24 hours, respectively) appeared to actually reduce time to exhaustion (0.8%, a clinically irrelevant degree) and suppressed the exercise-induced increase in insulin. Other biomarkers tested were unaltered, although heart rate trended to decrease with 3g citrulline