citrulline-blood-pressure

5,600mg of citrulline daily for 7 days in otherwise healthy middle aged men was able to improve blood flow secondary to nitric oxide, but did not influence blood pressure per se. The improvement in blood flow was correlated with the serum increases in arginine.

In heart failure patients with preserved ejection fraction, 3g of supplemental citrulline daily was able to promote cardiac function and reduce blood pressure. Arginine at 8g was equally effective, and this study lacked a placebo control.

In youth subject to a cold pressor test (which acutely increases blood pressure) noted that 4 weeks of citrulline supplementation at two daily doses of 3g (6g total) was able to attenuate the rise in systolic but not diastolic blood pressure relative to baseline.