| 効果 | 減少 |
| 試験方法 | コホート法 |
| 試験期間 | 6+ ヶ月 |
| 被験者数 | 20 |
| 性別 | 女性 |
| 年齢 | 45-64 |
| 体型 | 肥満 |
25mg of DHEA over 12 months was able to increase all steroid hormones in the serum, including the neurosteroids allopregnanolone and beta-endorphin. SHBG also decreased alongside cortisol, and overall menopausal symptoms in these women was decreased.
Dhea Supplementation And Cognition In Postmenopausal Women
| 効果 | 増加 |
| 試験方法 | 二重盲検法 |
| 試験期間 | 不明 |
| 被験者数 | 20 |
| 性別 | 不明 |
DHEA at 25mg for 6 months was associated with an increased cortisol level at varying points of the day in postmenopausal females (tested on the last day of the trial); however, the treatment group was significantly heavier at baseline which may have influenced the results.
Long-term Low-dose Oral Administration Of Dehydroepiandrosterone Modulates Adrenal Response To Adrenocorticotropic Hormone In Early And Late Postmenopausal Women
| 効果 | 減少 |
| 試験方法 | 二重盲検法 |
| 試験期間 | 6+ ヶ月 |
| 被験者数 | 20 |
| 性別 | 女性 |
| 年齢 | 45-64 |
| 体型 | 肥満, 平均 |
Circulating steroids increased after low dose (25mg) DHEA administration for up to a year, yet after 3 months of supplementation cortisol appeared to decline and the adrenal glands released less cortiol in response to ACTH hormone stimulation; suggesting a modification of the stress response. 17-hydroxyprogresterone only increased during months 6-12, not month 3.
Subjects were otherwise healthy menopausal women aged 50-65/
Six-month Oral Dehydroepiandrosterone Supplementation In Early And Late Postmenopause
| 効果 | 減少 |
| 試験方法 | 二重盲検法 |
| 試験期間 | 1-6 ヶ月 |
| 被験者数 | 36 |
| 性別 | 女性 |
| 年齢 | 45-64 |
| 体型 | 肥満, 平均 |
50mg of DHEA over 6 months in menopausal women showed that testosterone and estrogen increased, while SHBG decreased only in overweight women significantly. Plasma levels of neurosteroids (beta-endorphin and allopregnanolone) increased while cortisol and gonadotropins decreased.
SHBG decreased only in the subset of postmenopausal women who were older and overweight.
Supplementation With DHEA: Effect On Muscle Size, Strength, Quality Of Life, And Lipids
| 効果 | なし |
| 試験方法 | 二重盲検法 |
| 試験期間 | 1-6 ヶ月 |
| 被験者数 | 50 |
| 性別 | 女性 |
| 年齢 | 45-64, 65+ |
DHEA at 50mg daily in menopausal women does not influence muscle mass, libido, sleep quality or well being despite increasing circulating androgen status. Estrone and SHBG were unaffected alongside cortisol. Functional tests failed to show a protective effect of either DHEA or estrogen replacement therapy (active control) and power output (knee flexion) was unaffected. Cholesterol decreased 8%.
