conjugated-linoleic-acid-lean-mass

この研究の注釈：

7 weeks of 5g CLA was more effective than placebo at increasing lean mass (males only) and reducing fat vicariously through weight training in otherwise healthy and moderately active 18-45 year olds.

Lean mass increased from 55.5+/-12.1kg to 56.8+/-13 in CLA, yet increased by 0.2kg in placebo; fat mass decreased by 0.8kg in CLA and increased 0.4kg in placebo.

この研究の注釈：

In healthy overweight humans, CLA taken at 3.4g for 2 years was able to reduce fat mass and did not influence lean mass.

Aspartate Amino transferase (liver enzyme) increased, but alanine amino transferase did not. Glucose was unchanged, body fat mass was reduced by 1.7+/-2.8kg over 2 years with no effects in the first year; bone mineral density and lean mass were unaffected.

この研究の注釈：

4.5g CLA (80% main isomers in a 50/50 split at 40% each) in overweight but otherwise healthy humans was able to turn a 0.2kg fat gain in placebo to a −1.1 ± 3.7kg weight loss (with CLA in free fatty acid form) or −1.8 ± 3.4kg (CLA triglycerides), body fat decreased and lean mass increased (1.7-2.4kg average loss, 0.6-0.7kg average gain) with no significant differences between dietary intake or exercise.

この研究の注釈：

In obese but otherwise healthy persons, CLA for 12 weeks at 6.4g was able to increase lean mass by 0.64kg (3.2g CLA uneffective); this was accompanied by increased markers of inflammation (IL-6, C-RP). Fat showed a trend to decline, but was insignificant.

More side-effects reported in 6.4g CLA group, mostly gastrointestinal in nature.

この研究の注釈：

Men divided into four groups (young and old; lean and obese) and given 2.28g CLA daily alongside 1.28g [Fish Oil] found no significant changes in any measured parameters, except for a decrease in fat mass and increase in lean mass in the young and obese group; a loss of 83g fat mass relative to placebo gaining 742g fat mass (0.82kg difference) over 12 weeks.

Adiponectin increased in youth (9% lean, 12% obese) and not in the older group.

この研究の注釈：

Men divided into four groups (young and old; lean and obese) and given 2.28g CLA daily alongside 1.28g [Fish Oil] found no significant changes in any measured parameters, except for a decrease in fat mass and increase in lean mass in the young and obese group; a loss of 83g fat mass relative to placebo gaining 742g fat mass (0.82kg difference) over 12 weeks.

Adiponectin increased in youth (9% lean, 12% obese) and not in the older group.

この研究の注釈：

Doses above 3.4g CLA for 12 weeks (3.4, 5.1, 6.4) was associated with a decrease in fat mass and increase in lean body mass as assessed by DEXA without changes in weight, in overweight and obese humans.

Most dramatic numbers were seen with 3.4g (no dose-response noted) and were -1.73kg fat mass with +1.26kg lean mass; high inter-individual variability.

この研究の注釈：

12 weeks of 1.7g CLA in overweight and obese chinese persons was able to reduce body weight and fat mass, with seemingly more efficacy in obese persons (BMI greater than 27) and with females getting more benefit than males.

0.69kg loss over 12 weeks, statistically but not clinically significant.

この研究の注釈：

Over 16 weeks, obese and diabetic postmenopausal women given CLA at a dose of 8g daily reduced fat mass with no influence on lean mass when compared to safflower oil.

Fairly high dropout rate (55 to 35) with no differences between CLA or safflower.

この研究の注釈：

In healthy and exercising normal weight men and women, CLA at 4g daily for 12 weeks was unable to influence parameters of body composition.

Women had reductions in both HDL and LDL, and lower insulin concentrations.

この研究の注釈：

Metabolic rate was found to be increased in this study, which was testing whether CLA could reduce the rate of weight regain after a very-low calorie diet.

The increase in metabolic rate was secondary to CLA influencing more weight regain to lean mass rather than fat mass, when compared to placebo oil, at 1.8 and 3.6g CLA daily for 13 weeks.

この研究の注釈：

Metabolic rate was found to be increased by 4% relative to baseline over 14 weeks of consuming CLA-enriched yoghurt, despite no changes in fat mass or weight being noted; this was in comparison to non-CLA enhanced yoghurt, and without significant dietary control.

Odd method of statistical significance, metabolic rate in relation to overall mass was significant at P=0.07 (not normally accepted) but significant at P=0.03 (accepted) when in relation to fat free mass, which is what is touted in the abstract.

この研究の注釈：

Relative to safflower oil as a control at 3.5g daily, two experimental groups were used. 3.5g of oil comprising 2.7g of 50/50 CLA isomers, and 3.5g oil comprising 2.7g of jsut the c9t11 isomer. Population was overweight and hyperlipidemic men, and no dietary controls were in place (free-living conditions) over 56 days.

No differences existed in lean mass, fat mass, or weight; nor were any trends noted. A decrease in circulating TNF-a was noted with both CLA treatments, and all other parameters came back statistically insignificant.