Lack Of Prophylactic Efficacy Of An Enteric-coated Bovine Hyperimmune Milk Product Against Enterotoxigenic Escherichia Coli Challenge Administered During A Standard Meal

効果 なし
試験方法 二重盲検法
試験期間 1-7 Days
被験者数 20
性別 男女
この研究の注釈：

Supplementation of colostrum (immunized against E.coli) in enteric capsules failed to exert protective effects against E.coli-induced diarrhea relative to placebo.

Randomized Control Trials Using A Tablet Formulation Of Hyperimmune Bovine Colostrum To Prevent Diarrhea Caused By Enterotoxigenic Escherichia Coli In Volunteers

効果 なし
試験方法 二重盲検法
試験期間 24 hours
被験者数 90
性別 男女
年齢 18-29
この研究の注釈：

400mg of immunized bovine colostrum given to participants prior to a meal (and with this meal, E.coli infection to induce diarrhea) and twice daily at other times appears to reduce diarrhea as well as intestinal pain related to the diarrhea relative to placebo; overall amount of E.coli recovered in the feces was not altered.

Protection By Milk Immunoglobulin Concentrate Against Oral Challenge With Enterotoxigenic Escherichia Coli

効果 なし
試験方法 コホート法
試験期間 1-2 週間
被験者数 20
性別 男女
年齢 18-29, 30-44
この研究の注釈：

Supplementation of colostrum immunized against E.coli given 3.55g of the immunoglobulins thrice daily taken 15 minutes after meals for one week prior to being fed E.coli prevented diarrhea from E.coli ingestion despite diarrhea still occuring in the control group given the colostrum immunized against rotavirus. Total E.coli in the feces did not appear to be altered with immunized colostrum.